Complejidad y dimensiones en los estudios sobre Babbage: la máquina analítica. Un análisis del fracaso cultural del primer proyecto de calculadora digital programable secuencialmente.

En este artículo se analiza el caso histórico de la máquina analítica de Babbage junto con algunos otros ejemplos relacionados, con la intención de comprender qué tipo de condiciones retrasaron el advenimiento de la > hasta un siglo después de los primeros diseños de calculadoras programables multi-propósito. La respuesta a este interrogante proviene de una hibridación entre el enfoque socioeconómico de los estudios de ciencia, tecnología y sociedad y la teoría de la complejidad aplicada a los fenómenos sociales en la historia de la técnica. Como conclusión se prueba que el propio Babbage pudo ser consciente de estas constricciones en la estructura social de los medios de producción que retrasarían la emergencia del cálculo automático durante un siglo.This article analyses the historical case of the Babbage's machine and other related examples in order to understand the conditions delaying the coming of the •computer revolution· during one century since the first designs of programmable calculators. The response derives from the joining of both che STS socioeconomic approach and the complexity theory applied to social phenomena in the history of technology. As a result, it is showed that Babbage could be conscious of these constrictions in the social structure, which would be responsible for the delay of the emergence of automatic calculus during one century

Quantum East model: localization, non-thermal eigenstates and slow dynamics

We study in detail the properties of the quantum East model, an interacting quantum spin chain inspired by simple kinetically-constrained models of classical glasses. Through a combination of analytics, exact diagonalization and tensor-network methods we show the existence of a transition, from a fast to a slow thermalization regime, which manifests itself throughout the spectrum. On the slow side, by exploiting the localization of the ground state and the form of the Hamiltonian, we explicitly construct a large (exponential in size) number of non-thermal states which become exact finite-energy-density eigenstates in the large-size limit, as expected for a true phase transition. A ``super-spin'' generalization allows us to find a further large class of area-law states proved to display very slow relaxation. These states retain memory of their initial conditions for extremely long times. Our numerical analysis reveals that the localization properties are not limited to the ground state and that} many eigenstates have large overlap with product states and can be approximated well by matrix product states at arbitrary energy densities. The mechanism that induces localization to the ground state, and hence the non-thermal behavior of the system, can be extended to a wide range of models including a number of simple spin chains. We discuss implications of our results for slow thermalization and non-ergodicity more generally in disorder-free systems with constraints and we give numerical evidence that these results may be extended to two dimensional systems.Comment: 21 pages, 16 figure

Poliomyelitis surveillance report number 18, May 20, 1955

Dr. Edwin Lennette, Virus Laboratory, California Department of Public Health, reports isolation of type 1 virus from the stool of case PSU No. Cal-21. He also reports isolation of type 1 virus from the stool of a third \uc2\ub0th contact of non-paralytic case PSU No. Cal-14. Isolations from 2 other contacts of this case were previously reported.Dr. Werner Henle, Children\ue2\u20ac\u2122s Hospital, Philadelphia, reports isolation of type 1 poliomyelitis virus from Case PSU No. Pa-2. This is the first isolation from a case receiving Wyeth Vaccine. This case had first paralysis at the same site as inoculation.One new case was accepted today from West Virginia. This seven-year-old female developed bulbar signs 26 days after inoculation with Lilly Vaccine. Vaccinated cases total 79 at 12:00 noon 5-20-55 (Table l)

Leptogenesis in a Realistic Supersymmetric Model of Inflation with a Low Reheat Temperature

We discuss leptogenesis in a realistic supersymmetric model of inflation with a low reheat temperature 1-10 GeV. The lepton asymmetry is generated by a decaying right handed sneutrino, which is produced after inflation during preheating. The inflationary model is based on a simple variant of the Next-to-Minimal Supersymmetric Standard model (NMSSM) which solves the \mu problem, called \phiNMSSM, where the additional singlet \phi plays the role of the inflaton in hybrid (or inverted hybrid) type models. The model is invariant under an approximate Peccei-Quinn symmetry which also solves the strong CP problem, and leads to an invisible axion with interesting cosmological consequences. We show how the baryon number of the universe and the nature of cold dark matter are determined by the same parameters controlling the strong CP problem, the \mu problem and the neutrino masses and mixing angles.Comment: 17 page, latex, 1 eps fi

Nut production in Bertholletia excelsa across a logged forest mosaic: implications for multiple forest use

Although many examples of multiple-use forest management may be found in tropical smallholder systems, few studies provide empirical support for the integration of selective timber harvesting with non-timber forest product (NTFP) extraction. Brazil nut (Bertholletia excelsa, Lecythidaceae) is one of the world’s most economically-important NTFP species extracted almost entirely from natural forests across the Amazon Basin. An obligate out-crosser, Brazil nut flowers are pollinated by large-bodied bees, a process resulting in a hard round fruit that takes up to 14 months to mature. As many smallholders turn to the financial security provided by timber, Brazil nut fruits are increasingly being harvested in logged forests. We tested the influence of tree and stand-level covariates (distance to nearest cut stump and local logging intensity) on total nut production at the individual tree level in five recently logged Brazil nut concessions covering about 4000 ha of forest in Madre de Dios, Peru. Our field team accompanied Brazil nut harvesters during the traditional harvest period (January-April 2012 and January-April 2013) in order to collect data on fruit production. Three hundred and ninety-nine (approximately 80%) of the 499 trees included in this study were at least 100 m from the nearest cut stump, suggesting that concessionaires avoid logging near adult Brazil nut trees. Yet even for those trees on the edge of logging gaps, distance to nearest cut stump and local logging intensity did not have a statistically significant influence on Brazil nut production at the applied logging intensities (typically 1–2 timber trees removed per ha). In one concession where at least 4 trees ha-1 were removed, however, the logging intensity covariate resulted in a marginally significant (0.09) P value, highlighting a potential risk for a drop in nut production at higher intensities. While we do not suggest that logging activities should be completely avoided in Brazil nut rich forests, when a buffer zone cannot be observed, low logging intensities should be implemented. The sustainability of this integrated management system will ultimately depend on a complex series of socioeconomic and ecological interactions. Yet we submit that our study provides an important initial step in understanding the compatibility of timber harvesting with a high value NTFP, potentially allowing for diversification of forest use strategies in Amazonian Perù

Constraints on the gluon PDF from top quark pair production at hadron colliders

Using the recently derived NNLO cross sections \cite{Czakon:2013goa}, we provide NNLO+NNLL theoretical predictions for top quark pair production based on all the available NNLO PDF sets, and compare them with the most precise LHC and Tevatron data. In this comparison we study in detail the PDF uncertainty and the scale, $m_t$ and $\alpha_s$ dependence of the theoretical predictions for each PDF set. Next, we observe that top quark pair production provides a powerful direct constraint on the gluon PDF at large $x$, and include Tevatron and LHC top pair data consistently into a global NNLO PDF fit. We then explore the phenomenological consequences of the reduced gluon PDF uncertainties, by showing how they can improve predictions for Beyond the Standard Model processes at the LHC. Finally, we update to full NNLO+NNLL the theoretical predictions for the ratio of top quark cross sections between different LHC center of mass energies, as well as the cross sections for hypothetical heavy fourth-generation quark production at the LHC.Comment: 29 pages, 13 figures, accepted for publication in JHE

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genome-wide significant loci comprising 49 distinct association signals. Effect sizes were largest for stage 3/4 disease, driven by ovarian endometriosis. Identified signals explained up to 5.01% of disease variance and regulated expression or methylation of genes in endometrium and blood, many of which were associated with pain perception/maintenance (SRP14/BMF, GDAP1, MLLT10, BSN and NGF). We observed significant genetic correlations between endometriosis and 11 pain conditions, including migraine, back and multisite chronic pain (MCP), as well as inflammatory conditions, including asthma and osteoarthritis. Multitrait genetic analyses identified substantial sharing of variants associated with endometriosis and MCP/migraine. Targeted investigations of genetically regulated mechanisms shared between endometriosis and other pain conditions are needed to aid the development of new treatments and facilitate early symptomatic intervention

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genome-wide significant loci comprising 49 distinct association signals. Effect sizes were largest for stage 3/4 disease, driven by ovarian endometriosis. Identified signals explained up to 5.01% of disease variance and regulated expression or methylation of genes in endometrium and blood, many of which were associated with pain perception/maintenance (SRP14/BMF, GDAP1, MLLT10, BSN and NGF). We observed significant genetic correlations between endometriosis and 11 pain conditions, including migraine, back and multisite chronic pain (MCP), as well as inflammatory conditions, including asthma and osteoarthritis. Multitrait genetic analyses identified substantial sharing of variants associated with endometriosis and MCP/migraine. Targeted investigations of genetically regulated mechanisms shared between endometriosis and other pain conditions are needed to aid the development of new treatments and facilitate early symptomatic intervention